Interactome Networks and Human Disease
Authors: M. Vidal, M. E. Cusick, A.-L. Barabasi
Publication Date: March 18, 2011
Journal: Cell 144, 986-995 (2011)
Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integratedwith each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.
